Lecithin and Stroke (Research)

Research Summary

Shi, 2001    Human   

Stroke patients received either conventional treatment, conventional treatment + CDP-choline, or conventional treatment + 30 grams of soybean lecithin per day, commencing within 48 hours of the occurrence of the stroke, and continuing for 28 days.    The conventional treatment + lecithin group had lower cerebral infarct volume than the other groups.  The lecithin group had the lowest nervous function defect of the 3 groups.  Authors conclude that lecithin is effective for the after-treatment of stroke and that the mechanims may be maintenance of brain phospholipids.
Peer-Reviewed Professional Journals

·    Shi, F., et al.  [Curative effect of soybean lecithin on cerebral infarction.]  Zhonghua Yi Xue Za Zhi.  81(21):1301-1303, 2001.

Department of Neurology, Genaral Hospital of Shengyang Military Command, Shengyang, China.

The objective of this study was to investigate the clinical curative effect of soybean lecithin on cerebral infarction.  542 patients with cerebral infarction within 48 h after the onset with the nervous fuction defect scores of 31-35 were divided into 3 groups:  basic treatment group, 60 cases, with conventional treatment; citicoline group, 122 patients, with conventional treatment and citicoline; and soybean lecithin group, 360 patients, with conventional treatment and soybean lecithin 10 g tid.  For all patients, treatment began sometime within 48 hours after the onset.  The treatment course lasted 28 days.  When the course was over, the infarct volumes in basic group citicoline group, and soybean lecithin group, were 7.6 cm3 +/- 2.9 cm3, 7.3 cm3 +/- 3.1 cm3, and 6.4 cm3 +/- 2.7 cm3 respectively (F = 7.371, P = 0.0007).  The basic group and citicoline group being compared with the soybean group by Dunnett test, t = 4.387 and 3.969 respectively, P < 0.01.  The nervous function defect integral in the 3 groups decreased 14.2 +/- 10.93, 15.0 +/- 9.0, and 18.5 +/- 10.9 respectively.  Two-way analysis of variance of drug kind and beginning time of treatment showed the value of F in drugs as 6.250, P = 0.0021, and value of F in times as 0.9417, P = 0.4201.  In the order of death, deterioration, nonimprovement, improvement, significant improvement, and recovery, the Ridit values for the comprehensive curative effect in the 3 groups were 0.4003, 0.4118, and 0.545 respectively; chi2 = 27.89, P < 0.001.  Soybean lecithin is effective in treatment of acute cerebral infarction. The mechanism may be that soybean lecithin lowers the decrease of brain phospholipid content in brain ischemia.